Historical Books, Reviews, and Symposia Proceedings

Books and Reviews

E.K. Frey, H. Kraut, E. Werle (eds.): "Kallikrein-Padutin". Ferdinand Enke Verlag Stuttgart 1950 

E.K. Frey, H. Kraut, E. Werle (eds.): "Das Kallikrein-Kinin-System und seine Inhibitoren". Ferdinand Enke Verlag, Stuttgart 1968

M. Rocha e Silva (ed.): "Kinin Hormones with Special Reference to Bradykinin and Related Kinins" Charles C. Thomas Publisher, Springfield Illinois-USA, 1970

E.G. Erdös, A.F. Wilde (eds.): "Bradykinin, Kallidin and Kallikrein". Handbook of Experimental Pharmacology, Volume XXV. Springer Verlag Berlin . Heidelberg . New York, 1970

E.G. Erdös (ed.): "Bradykinin, Kallidin and Kallikrein". Handbook of Experimental Pharmacology, Volume XXV. Supplement. Springer Verlag Berlin . Heidelberg . New York, 1979

H. Fritz, I. Schmid, G. Dietze (eds.): The Kallikrein-Kinin System in Health and Disease. International Symposium 1988. Limbach-Verlag Braunschweig 1989.

Recent Progress on Kinins: Proceedings of the International Conference „Kinin 91 Munich“ held in Munich Sept. 8-14, 1991. Agents and Actions Supplements Vol. 38. Birkhäuser Verlag Basel 1992.
38/I - Biochemistry and Molecular Biology of the Kallikrein-Kinin System. H. Fritz, W. Müller-Esterl, M. Jochum, A. Roscher, K. Luppertz (eds.)
38/II - Pharmacological and Clinical Aspects of the Kallikrein-Kinin System. G. Bönner, H. Fritz, Th. Unger, A. Roscher, K. Luppertz (eds.)
38/III - Clinical Aspects of the Kallikrein-Kinin System. G. Bönner, H, Fritz, B. Schoelkens, G. Dietze, K. Luppertz (eds.).

K.D. Bhoola, C.D. Figueroa, K. Worthy: Bioregulation of Kinins: Kallikreins, Kininogens, and Kininases. Pharmacological Reviews, 44, 1-80 (1992)

M. E. Moreau, N. Garbacki, G. Molinaro, N.J. Brown, F. Marceau, A. Adam: The kallikrein-kinin system: Current and future pharmacological targets. J. Pharmacol. Sci., 99, 6-38 (2005)

M. Bader (ed.): KININS. Walter de Gruyter, Berlin / Boston, 2011
This handbook of kinin biology and biochemistry covers the current knowledge of kinins, a family of peptides involved in numerous physiological and pathophysiological processes. Recent publications have shown that the kinin system is highly relevant in a variety of disease states such as diabetes, multiple sclerosis and traumatic injuries. Furthermore, the first drug targeting system has just been approved for clinical use. The goal of this book is to provide advanced students and researchers a basic understanding of the kinin system and its role within the various organ systems.

V. Magdolen, C. P. Sommerhoff, H. Fritz, M. Schmitt: Kallikrein-related peptidases. Volume 1: Characterization, regulation, and interactions within the protease web. Walter de Gruyter, Berlin / Boston, 2012
This handbook is the first comprehensive book of its kind reviewing the clinically relevant current status of tissue kallikrein and kallikrein-related peptidases research. Since several members of the KLK family are key players in (patho-)physiological processes, structural, functional, and regulatory studies are under way to develop new strategies to prevent and treat disorders to which individual members of the KLK protease family contribute significantly. The goal of this book is to inform clinicians, physician scientists and researchers about the prominent role of the multifaceted and interactive KLK system in normal physiology and pathological organ function.

V. Magdolen, C. P. Sommerhoff, H. Fritz, M. Schmitt: Kallikrein-related peptidases. Volume 2: Novel cancer-related biomarkers. Walter de Gruyter, Berlin / Boston, 2012
Various KLK proteins and their encoding genes have attracted increased attention among scientists and clinicians worldwide since they represent very interesting and functionally distinct biomarkers, particularly, in cancer. This book reviews the role of kallikrein-related peptidases (KLKs) in a wide range of cancers, including lung, prostate, breast and ovarian cancer. It provides clinicians, physician scientists and researchers with a comprehensive overview on the clinical relevance of KLK expression in various malignancies.

International Symposia Proceedings

"Kininogenases – Kallikreins: Physiological Properties and Pharmacological Rationale". G.L. Haberland, J.W. Rohen, P. Huber, H. Fritz, G. Blümel, C. Schirren. T. Suzuki (eds.). F.K. Schattauer, Stuttgart – New York 1973, 1975, 1975, 1977, 1981, 1983, 1986.

"KININ 2000, Munich/Germany: KININS 1925-2000"
Biol. Chem. 382/1, 3-139 (2001)

"KININ 2005, Lund/Sweden: Exploring the Future of Local Vascular and Inflammatory Mediators"
Biol. Chem. 387/2, 117-234 (2006)

"IKS 2005, Lausanne/Switzerland: Kallikreins and Kallikrein-Related Peptidases"
Biol. Chem. 387/6, 635-824 (2006)

"KININ 2007, Berlin/Germany: Comeback for Kinins"
Int. Immunopharmacol. 8/2, 133-378 (2008)

"IKS 2007, Santorini Island/Greece: Kallikreins and Kallikrein-Related Peptidases"
Biol. Chem. 389/6, 619-786 (2008)

"Peptide Receptors & Kinin 2009, Quebec City/Canada"
Neuropeptides 44/3, 215-284 (2010)

"IKS 2009, Munich/Germany: Kallikreins and Kallikrein-Related Peptidases"
Biol. Chem. 391/4, 295-479 (2010)

"ISK 2011, Rhodes Island, Greece: The 4th International Symposium on Kallikreins and Kallikrein-Related Peptidases"
Biol. Chem. 393/5, 299-427 (2012)

"KININ 2012 Paris: Third International Symposium on Vasoactive and Inflammatory Mediators"
Biol. Chem. 394/3, 317–432 (2013)

"ISK 2013 Toronto, Canada: The 5th International Symposium on Kallikreins and Kallikrein-Related Peptidases"
Biol. Chem. 395/3, 913–1132 (2014)

"KININ 2015 São Paulo, Brazil: The Kinin 2015 International Meeting on Kinin on Kinin System and Peptide Receptors"
Biol. Chem. 397/4, 281–372 (2016)

"ISK 2015 Brisbane, Australia: The 6th International Symposium on Kallikreins and Kallikrein-Related Peptidases - remodelling the
KLK landscape down under"
Biol. Chem. 397/12, 1215–1313 (2016)

Reviews and News

Ahimastos AA, Walker PJ, Askew C, Leicht A, Pappas E, Blombery P, Reid CM, Golledge J, Kingwell BA. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA 2013;309(5):453-60.

Kränkel N, Kuschnerus K, Müller M, Speer T, Mocharla P, Madeddu P, Bader M, Lüscher TF, Landmesser U. Novel insights into the critical role of bradykinin and the kinin B2 receptor for vascular recruitment of circulating endothelial repair-promoting mononuclear cell subsets: alterations in patients with coronary disease. Circulation 2013;127(5):594-603.

Dasgupta, A. Is a Bradykinin Storm Brewing in COVID-19? (2020). www.the-scientist.com/news-opinion/is-a-bradykinin-storm-brewing-in-covid-19--67876

Garvin MR, Alvarez C, Miller JI, Prates ET, Walker AM, Amos BK, Mast AE, Justice A, Aronow B, Jacobson D, A mechanistic model and therapeutic interventions for Covid-19 involving a RAS-mediated bradykinin storm. eLife 2020;9:e59177. DOI: https//doi.org/10.7554/eLife.59177