Activities of the Foundation

Since its establishment in 1988, the E.K. Frey – E. Werle Foundation has supported scientific conferences and symposia with nearly 600,000 US$ in total. The awards and laudation speeches have been presented by the former President of the LMU, Prof. Dr. Wulf Steinmann (1988-1995) and subsequently by Prof. Dr. Werner Müller-Esterl and Prof. Dr. Hans Fritz. Some of the laudatios have been published in Immunopharmacology 43, 91-95 (1999) and 32, 2-5 (1996) as well as in Agents & Actions, Suppl. 38/I, 8-17 (1992).

Recipients of the Awards

1988	International Symposium on the occasion of the 100th birthday anniversary of E.K. Frey: 'The Kallikrein-Kinin System in Health and Disease', Munich, Germany
	Medal	Ervin G. Erdös (USA)
	Prize	Gerd Bönner (Germany) & Walter Jauch (Germany)

1989	Symposium '20 Years of Research by SFB 51 and SFB 207 of LMU Munich' with Academic Celebration in the Aula of the LMU, Munich, Germany
	Medal	Robert Huber (Germany)
	Prize	Wolfram Bode (Germany)

1991	International Conference KININ '91 Munich, Germany
	Medal	John M. Stewart (USA)
	Prize	Carlos D. Figueroa (Chile) & Alvin H. Schmaier (USA)

1993	International Conference KININ '93 Brazil, Guarujá (Sao Paulo), Brazil
	Medal	Sergio H. Ferreira (Brazil)
	Prize	Kurt Jarnagin (USA) & David Proud (USA)

1994	International Conference on KININS, Montreal, Canada
	Medal	Domenico Regoli (Canada)
	Prize	Bernward A. Schoelkens (Germany)

1995	International Conference KININ '95 Denver, USA
	Medal	Mel Schachter (UK)
	Prize	Julie Chao (USA) & Lee Chao (USA)

1996	International Conference KININ '96 Durban, South Africa
	Medal	Kanti D. Bhoola (South Africa)

1997	Gordon Research Conference on Kallikreins and Kinins, Barga, Italy
	Medal	Harry S. Margolius (USA)
	Prize	François Alhenc-Gelas (France)

1998	International Conference KININ '98, Nara, Japan
	Medal	Hiroshi Maeda (Japan)
	Prize	Fredrik Leeb-Lundberg (USA, Sweden)
	Honorary Membership Silver Medal	Sadaaki Iwanaga (Japan)

1998	3rd Symposium 'From Increased Energy Metabolism to Cardiac Hypertrophy and Failure', Baden-Baden, Germany
	Medal	Victor J. Dzau (USA)

2000	International Conference KININS 1925 - 2000 MUNICH, organized by the E.K. FREY – E. WERLE Foundation
	Honorary Membership Silver Medal	Oscar A. Carretero (USA) Judith Clements (Australia) Robert W. Colman (USA) Alan W. Cuthbert (England) Günther Dietze (Germany) Lowell M. Greenbaum (USA) Sadaaki Iwanaga (Japan) Allen P. Kaplan (USA) Makoto Katori (Japan) Klaus Peter (Germany) Claudio A. M. Sampaio (Brazil) Kazuaki Shimamoto (Japan)

2002	International Conference KININ '02, Charleston, USA
	Medal	Hans Fritz (Germany)
	Prize	Fred Hess (USA)

2005	1st International Conference 'Exploring the Future of Local Vascular and Inflammatory Mediators', Lund, Sweden
	Medal	Rudi Busse (Germany)
	Prize	François Marceau (Canada)

2007	KININ 2007: 2nd International Conference 'Exploring the Future of Vascular and Inflammatory Mediators', Berlin, Germany
	Medal	Oliver Smithies (USA)
	Prize	João Pesquero (Brazil)

2007	2nd International Symposium on 'Kallikreins & Kallikrein-related Peptidases', Santorini Island, Greece
	Medal	Judith Clements (Australia)

2007	5th General Meeting of the International Proteolysis Society, Patras, Greece
	Medal	Eleftherios Diamandis (Canada)

2008	43rd Annual Meeting of the German Diabetes Association, Munich, Germany
	Medal	Erik John Henriksen (USA)

2009	5th International Symposium on Peptide Receptors & KININ 2009, Québec City, Canada
	Medal	Werner Müller-Esterl (Germany) Oscar Carretero (USA)
	Prize	Nancy Brown (USA)

2009	3rd International Symposium on Kallikreins and Kallikrein-related Petidases, Munich, Germany
	Medal	Michael Blaber (USA)
	Prize	Andreas Scorilas (Greece)
	Young Investigator Award	Katerina Oikonomopoulou (Canada)

2011	4th International Symposium on Kallikreins and Kallikrein-related Peptidases, Rhodes Island, Greece
	Prize	Viktor Magdolen (Germany)
	Young Investigator Award	Konstantinos Mavridis (Greece)

2012	3rd International Symposium on Vasoactive and Inflammatory Mediators - KININ 2012, Paris, France
	Medal	Pierre Corvol (France)
	Prize	Randal Skidgel (USA)
	Young Investigator Award	Maria Campos (Brazil)

2013	5th International Symposium on Kallikreins and Kallikrein-related Peptidases, Toronto, Canada
	Medal	Morley D. Hollenberg (Canada)
	Prize	Georgia Sotiropoulou (Greece)
	Young Investigator Award	Ulf Meyer-Hoffert (Germany)

2015	International Meeting Kinin System and Peptide Receptors - KININ 2015 Brazil, São Paulo
	Medal	Michael Bader (Germany)
	Prize	Ronaldo de Carvalho Araujo (Brazil)
	Membership Silver Medal	João Calixto Batista (Brazil)

2015	6th International Symposium on Kallikreins and Kallikrein-Related Peptidases KLKs, ISK 2015 Brisbane, Australia
	Medal	Manfred Schmitt (Germany)
	Prize	Isobel Scarisbrick (USA)
2017	7th International Symposium on Kallikreins and Kallikrein-Related Peptidases, ISK 2017 Tours, France
	Medal	George Yousef (Canada)
	Prize	Peter Goettig (Austria)
	Young Investigator Award	Thomas Kryza (Australia)
2018	KININ 2018 CLE: International Kinin Meeting, Cleveland, Ohio, USA
	Medal	François Alhenc-Gelas (France)
	Prize	Thomas Renné (Germany)
	Young Investigator Award	Coen Maas (The Netherlands)
2019	8th International Symposium on Kallikreins and Kallikrein-Related Peptidases ISK 2019 , Prague, Czech Republic
	Prize	Daniela Loessner (Germany)
	Young Investigator Award	Srilakshmi Srinivasan (Australia)
2022	"KININ 2022", Annecy, France
	Medal	Julio Scharfstein (Brasil)
	Prize	Björn B. Burckhardt (Germany)

 

 

Rationale of the Awards of the Recipients

E.K. Frey - E. Werle Commemorative Gold Medalists

	Medalists	Major Topics
1988	Ervin Erdös USA	Peptide hormone cleaving enzymes Kininases
1989	Robert Huber Germany	Structures and functions of proteases and protease inhibitors
1991	John Stewart USA	Design and synthesis of kinin agonists and antagonists
1993	Sergio Ferreira Brazil	ACE inhibition by bradykinin potentiating peptides Antihypertensives and peripheral analgesics
1994	Domenico Regoli Canada	Receptor pharmacology of kinins and other neuropeptides
1995	Mel Schachter UK	Comparative pharmacology of bradykinin, kallidin and wasp kinin (KININ term introduced)
1996	Kanti Bhoola South Africa	Functional roles of kinins and their molecular mechanisms of action Localization of components of the KKS
1997	Harry Margolius USA	KKS in hypertension, diabetes, epithelial transport and central nervous system
1998	Hiroshi Maeda Japan	KKS in infectious diseases and inflammation Parasitic proteases and KKS
1999	Victor Dzau USA	Physiology and pathophysiology of the renin-angiotensin system
2002	Hans Fritz Germany	Structures, functions and biological roles of kallikreins, proteases and their inhibitors
2005	Rudi Busse Germany	Endothelium: Control of vascular tone and homeostasis (kinins, NO)
2007	Oliver Smithies USA	Gene targeting technology: Role of kinins and other cardiovascular hormones
2007	Judith Clements Australia	Gene locus of tissue kallikrein family KLK peptidases in hormone-dependent cancers
2007	Eleftherios Diamandis Canada	Tissue kallikrein gene family KLK peptidases as cancer biomarkers
2008	Eric Henriksen USA	Significance of the RAS und KKS in the modulation of insulin action in skeletal muskle tissue
2009	Werner Müller-Esterl Germany	Kininogens, kinin receptors, and ACE inhibitors: Structures and functions
2009	Oscar Carretero USA	KKS and RAS in blood pressure regulation, renal function, and organ damage
2009	Michael Blaber USA	KLK peptidases: Structural biology, enzymology and activation profiles
2012	Pierre Corvol France	Renin-angiotensin system: structures, genetics, physiology and pathophysiology
2013	Morley Hollenberg Canada	Biological functions of KLKs and PARs
2014	Ervin G. Erdös USA	Gold Medalist 1988: "Pioneer in Medicine Award of the University of Chicago"
2015	Michael Bader Germany	Molecular biology of genes coding for cardiovascular hormones Development of transgenic technology in mouse and rat
2015	Manfred Schmitt Germany	Role and clinical relevance of proteolysis systems in gynecological tumors Clinical utility of KLK family members for prognosis of breast and ovarian cancer patients
2017	George M. Yousef Canada	Cloning of  7 novel KLK peptidase genes Characterization of the complete human kallikrein locus on chromosome 19 Expression pattern of KLK genes in human tissues
2018	François Alhenc-Gelas France	Cloning and function of ACE, ACE gene polymorphism, cardio- and nephroprotective effects of tissue kallikrein
2022	Julio Scharfstein Brazil	Role of KKS in Chagas Disease, identification of kinin signaling as key factor of pathogenicity in innate immunity with implications for parasitic infections

E.K. Frey - E. Werle Promotion Prize Recipients
(since 2015 jointly awarded together with the Henner-Graeff-Foundation)

	Recipients	Major Topics
1988	Gerd Bönner Germany	Renal KKS in arterial hypertony Clinical pharmacology of ACE inhibitors
	Karl-Walter Jauch Germany	Kinins & ACE inhibitors in regenerative metabolism
1989	Wolfram Bode Germany	Proteinases, inhibitors, substrates: Xray structures, molecular mechanism of interactions
1991	Carlos Figueroa Chile	Cellular localization of tissue-kallikreins and kininogens Role of the KKS in the inflammatory response
	Alvin H. Schmaier USA	Kininogens: Functions, reaction mechanisms, interactions with coagulant and inflammatory cells
1993	Kurt Jarnagin USA	The bradykinin receptor: Molecular biology and pharmacology
	David Proud USA, Canada	Role of kinins in the pathogenesis of allergic rhinitis as base for new therapeutic approaches
1994	Bernward Schölkens Germany	Clinical efficacy of bradykinin receptor antagonists Cardioprotective effects of ACE inhibitors
1995	Julie Chao USA	Kallistatin, a new member of the serpin superfamily: Biochemistry, molecular biology, physiological function
	Lee Chao USA	Tissue kallikrein genes: Cloning, characterization, regulation, targeting to animal models for therapeutic approaches
1997	François Alhenc-Gelas France	Cloning and function of ACE, ACE gene polymorphism ACE as a cardiovascular and renal risk factor
1998	Fredrik Leeb-Lundberg USA, Sweden	Kinin receptors: Ligand binding, intracellular trafficking Kinin stimulated cellular pathways
2002	Fred Hess USA	Mammalian kinin receptors: Cloning, expression, structural/functional characterization, gene targeting
2005	François Marceau Canada	Kinin receptors: Molecular architecture, functional role in patho/physiology, therapeutic potential
2007	João Pesquero Brazil	Molecular biology of kinin receptors Patho/physiology of the KKS in transgenic knockout animal models
2009	Nancy Brown USA	Cardiovascular effects of the KKS in humans in health and disease
2009	Andreas Scorilas Greece	Clinical relevance of KLK peptidases, novel cancer- and apoptosis-related genes
2011	Viktor Magdolen Germany	Kallikrein-related petidases and the uPA system in cancer
2012	Randal Skidgel USA	Biological role of carboxypeptidases Novel concepts of kinin receptor signaling
2013	Georgia Sotiropoulou Greece	Biochemical and biological aspects of KLKs
2015	Ronaldo de Carvalho Araujo Brazil	Role of kinin B1 receptor in energy metabolism Inflammatory responses and neutrophil homeostasis
2015	Isobel Scarisbrick USA	Role of kallikrein-related peptidases in the central nervous system New strategies to introduce KLKs astargets for neuronal repair
2017	Peter Goettig Austria	Translation of activity regulation principles of kallikrein-related peptidases into clinical diagnosis and therapeutic strategies for cancer treatment
2018	Thomas Renné Germany	Translation of the mechanisms of Factor XII in thromboembolic and inflammatory diseases into therapeutic strategies for anticoagulant drugs with anti-inflammatory activities
2019	Daniela Loessner Germany	3D cell culture and orthotopic xenografts as biomarkers and for therapeutic targeting of advanced or chemoresistant ovarian cancer
2022	Björn B. Burckhardt Germany	Sophisticated mass spectrometry-based molecular analysis of kinins and their proteolysis products in tissues and bodily fluids

E.K. Frey - E. Werle Young Investigator Award

	Recipients	Major Topics
2009	Katerina Oikonomopoulou Canada	KLK peptidases: Expression in cancer and involvement in cell signalling
2011	Konstantinos Mavridis Greece	Influence of anticancer drugs on gene expression of kallikrein-related peptidases
2012	Maria Campos Brazil	Kinin, endothelin and chemokine receptors Inflammatory mediators in the nervous system
2013	Ulf Meyer-Hoffert Germany	Kazal-type protease inhibitors and KLKs
2017	Thomas Kryza Australia	Molecular mechanisms by which KLK peptidases regulate the tumor microenvironment in lung and prostate cancers Role of KLKs in progression and development of aggressive prostate cancers
2018	Coen Maas The Netherlands	Investigation of mechanisms of contact system andKKS in blood coagulation and hereditary angioedema
2019	Srilakshmi Srinivasan Australia	Prostate cancer risk-associated single nucleotide polymorphism affects PSA glycosylation and function